2020 ACR GUIDELINES
Pegloticase is STRONGLY RECOMMENDED for your patients with uncontrolled gout2*
For your uncontrolled gout patients who:
fail to normalize sUA levels on the maximum medically appropriate dose of ULTs
AND HAVE
(≥2 flares per year)
OR
nonresolving tophi
*In the KRYSTEXXA clinical trials, uncontrolled gout was defined as failure to normalize sUA under 6 mg/dL after at least 3 months of allopurinol treatment at the maximum medically appropriate dose or a self-reported contraindication.1,2
ACR, American College of Rheumatology; sUA, serum uric acid; ULT, urate-lowering therapy.